DNA Thrombotic Risk$195
DNA Thrombotic Risk
$195
Blood clots are painful and can be life-threatening. Do you carry genetic variants that increase the likelihood of developing blood clots?
What is thrombosis?
Thrombosis is when a blood clot forms inside a blood vessel and blocks the flow of blood through the circulatory system. Thrombotic risk refers to the likelihood of forming these dangerous blood clots.
- Online Results: Receive confidential results through a secure online portal, ensuring your privacy and peace of mind at every step.
- Painless Sampling: Collect your DNA samples with easy-to-use mouth swabs – no blood or needles required.
How It Works
Order
Order your kit online and collect your samples with the supplies inside your kit.
Send
When you're finished collecting your samples, simply mail them to the lab for analysis.
Receive your results
Receive confidential results in your secure online portal within 6-8 weeks after testing begins.
Results
Download your results from your secure online account as soon as they're ready.
Signs of a blood clot
Many factors contribute towards thrombotic risk, including a lack of mobility, smoking, obesity, surgery or injury, infections and disease, pregnancy, and hormonal changes.
However, “invisible” factors such as genetic changes that affect components of the blood clotting cascade also play a big role in your thrombotic risk.
Factor V Leiden mutation:
Factor V is a protein that promotes blood clotting. When it is not required, it is inactivated by protein C. The factor V Leiden mutation inhibits this inactivation, increasing the risk of abnormal blood clots.
Prothrombin G20210A mutation:
Prothrombin is another protein required for blood clot formation. In individuals carrying the G20210A variant in this gene there is an increase in prothrombin production, leading to an increased risk of abnormal blood clotting.
MTHFR mutations:
The MTHFR gene gives instructions to produce an enzyme involved in the conversion of folic acid to folate, which then helps convert homocysteine to methionine. Two MTHFR variants are linked to elevated homocysteine levels, known as hyperhomocysteinemia. Hyperhomocysteinemia increases the risk of abnormal blood clots.
Genetic Variants Analyzed
This test examines key genetic variants related to thrombophilia:
- F5 – Factor V Leiden mutation (1691G>A)
- F2 – Prothrombin mutation (20210G>A)
- MTHFR – Two mutations (677C>T and 1298A>C)
Each person inherits two copies of these genes—one from each parent. Possible genetic combinations include two normal copies (homozygous normal), two mutated copies (homozygous mutant), or one normal and one mutated copy (heterozygous). The specific combination of F5, F2, and MTHFR variants determines an individual’s risk for developing thrombophilia.
Understanding Your Results
-
Factor V Leiden Mutation (Heterozygous 1691G>A) – F5 Gene
- 3X to 8X increased risk of thrombosis
- 2X to 11X increased risk of miscarriage
-
Factor V Leiden Mutation (Homozygous 1691G>A) – F5 Gene
- 10X to 80X increased risk of thrombosis
- 2X to 11X increased risk of miscarriage
-
Prothrombin Mutation (Heterozygous 20210G>A) – F2 Gene
- 2X to 5X increased risk of thrombosis
- 2X to 3X increased risk of miscarriage
-
Prothrombin Mutation (Homozygous 20210G>A) – F2 Gene
- >5X increased risk of thrombosis
- 2X to 3X increased risk of miscarriage
-
MTHFR Mutation (Homozygous 677C>T)
- Increased risk of thrombosis if folate levels are low
-
MTHFR Mutations (677C>T and 1298A>C)
- Increased risk of thrombosis if folate levels are low
Frequently Asked Questions
How long does it take to get results?
Once your sample is received by our laboratory, processing usually takes 6-8 weeks. You will receive an email notification when your results are ready, and you can access your detailed report through a secure online portal.
Is my genetic information kept private?
We take data privacy seriously. Your results are confidential and only shared with you. We do not share your results with insurance companies, employers, or any other third parties.
Why DNA Tests Direct?
Accredited Excellence
Our laboratory holds globally recognized accreditations including AABB, CAP, CLIA, SCC, and ISO17025, ensuring accurate results for every test.
Your Privacy, Protected
Your privacy is our top priority. Our secure, accredited laboratory and password-protected online portal guarantee that your results are shared only with you.
Expert Support
Our dedicated customer care team is here to support you through the process, answer your questions, and provide any assistance you need.
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