
DNA Male Pair-Bonding AVPR1A Test
$149
What is the “male pair-bonding” gene?
The “male pair-bonding” gene is a genetic variant of the AVPR1A gene. AVPR1A variation can occur in the regulatory region of the gene at three different repetitive sequences, known as RS1, RS3 and GT25. A specific version of RS3, known as the RS3 334 allele, is associated with diminished pair-bonding in males.
Men with the RS3 334 allele are less likely to form a strong bond with their partners and are more likely to experience marital crisis or divorce. They are less likely to get married and more likely to cohabitate than individuals without the RS3 334 allele. Spouses of men with the RS3 334 allele report feeling less affection and consensus in the marriage.
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- Painless Sampling: Collect your DNA samples with easy-to-use mouth swabs – no blood or needles required.
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What is the AVPR1A gene?
The AVPR1A gene encodes the arginine vasopressin receptor 1A, which binds vasopressin and transmits the signal into the cells. Vasopressin is a hormone or chemical messenger that promotes water retention in the kidneys and increases blood pressure. Most of these effects take place when vasopressin is released into the blood stream. Vasopressin can also be released directly into the brain and influence social and sexual behavior (such as infidelity). When this signal transmission is disrupted, as in the case of “male pair-bonding” gene, there is a decreased likelihood of forming a strong bond with their partner.

The Genetics Behind Male Pair-Bonding
The AVPR1A gene, found on chromosome 12, plays a role in social bonding and relationship behaviors. Everyone inherits two copies of this gene—one from each parent. A simple DNA test can identify which variants of AVPR1A a person has. Differences in this gene are caused by short tandem repeats (STRs) in a regulatory region that affects protein levels. The AVPR1A STR test measures the length of these repeats to determine if an individual carries the RS3 334 variant, which has been linked to infidelity and pair-bonding tendencies.

Conditions Related to the AVPR1A Gene
Variations in the AVPR1A gene have been linked to a higher tendency for infidelity in both men and women. Additionally, other genetic changes in AVPR1A are associated with:
- Autism spectrum traits
- Altruistic tendencies
- Addictive behaviors
- Eating disorders
- Social interactions, including sibling relationships
Frequently Asked Questions
Once your sample is received by our laboratory, processing usually takes 6-8 weeks. You will receive an email notification when your results are ready, and you can access your detailed report through a secure online portal.
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